Pdf multifocal central giant cell granuloma a case report. Although central giant cell granulomas cgcgs appear to be benign, their radiographic findings are active. It is twice as common in females and is more likely to occur before age 30. It occurs most commonly in mandible, but can also occur in maxilla. Central giant cell granuloma cgcg is a relatively uncommon benign bony lesion of a variably aggressive nature. A case report with diagnostic dilemma garima singh 1, ashish thakur 2, heena sadiq 1, priti gupta 3 1 department of oral and maxillofacial pathology, i. It is actually an asymptomatic lesion which becomes evident during routine radiographic examination or as a result of painless but visible. Central giant cell granuloma is a benign intraosseous lesion of the jaws. This lesion is more common in border of mandible to the upper one third of gaertner. Central giantcell granulomas are more common in the anterior mandible, often crossing the midline and causing painless swellings. Central giantcell granuloma cgcg is a localised benign condition of the jaws. The affected patient was a 25 year old iraqi male who reported to us with recurrent pericoronitis in relation to lower left third molar.
Case report central giant cell granuloma of posterior maxilla. Central giant cell granuloma of the posterior maxilla. The case reported here resembled a wide variety of conditions that led to a misdiagnosis both on clinical and radiographic examinations but was histopathologically diagnosed as cgcg. The case presented in this article occurrence of central giant cell granuloma of the confirms to reported site, age, sex and jaw. The reported case is nonaggressive central giant cell granuloma of posterior mandible. It is considered widely to be a nonneoplastic lesion although formerly designated as.
Central giant cell granuloma of the mandibular condyle. A central giant cell granuloma in posterior part of maxillaa. To the best of our knowledge, the present case is the first report of recurrent cgcg of the nasal cavity and sinuses and its. Central giant cell granuloma cgcg is an uncommon benign bony lesion that occurs in the mandible and maxilla. Case report open access an aggressive central giant cell granuloma in a pediatric patient. For the previously reported cases in one female and three males, the mean age at presentation was 30 years. It is also known as giant cell epulis, osteoclastoma, giant cell reparative granuloma or giant cell hyperplasia.
Giant cell granuloma gcg is an uncommon, benign, proliferative, intraosseous lesion representing gran uloma is an intraosseous osteolytic lesion, with an unknown etiology, characterized by a benign pro liferation of fibroblasts and osteoclastlike giant cells, within a well vascularized stroma. We herein describe an intriguing case of a 21yearold male patient who. Correlating all clinical features and all investigation we finally diagnosed this case as central giant cell granuloma. Surgical treatment and reconstruction for central giant. Radiologically, it is usually a welldefined radiolucent defect with hazy opacity, classically described. Multifocal central giant cell granuloma a case report article pdf available in iranian journal of pathology 1. Central giant cell granuloma cgcg is a relatively uncommon benign bony lesion of a variably aggressive nature, accounting for less than 7% of all benign jaw lesions. Central giant cell granuloma formerly called as giant cell reparative granuloma is a non neoplastic proliferative lesion of unknown etiology. Jul 20, 20 central giant cell granuloma cgcg is a relatively uncommon benign bony lesion of a variably aggressive nature, accounting for less than 7% of all benign jaw lesions. Central giant cell granuloma cgcg is a benign intraosseous lesion of the jaws that is found predominantly in children and young adults. Central giant cell granulomas of the condyle are rare.
The lesion was removed by curettage and a histopathological examination was carried out. Central giant cell granuloma cgcg is a benign intraosseous lesion that occurs in long bones. Central giant cell granuloma cgcg is an uncommon benign intraosseous lesion of the jaw, found predominantly in children and young adults below 30 years of age. Belonging to the group of giant and cystic cell lesions of the 4th edition of the head and neck tumours classification by who, the central giant cell gran uloma is an intraosseous osteolytic lesion, with an unknown etiology, characterized by a benign pro liferation of fibroblasts and osteoclastlike giant cells, within a well vascularized stroma. Central giant cell granuloma cgcg of the jaws is a benign, intraosseous, osteolytic lesion of debatable etiology.
The case described here involved maxilla which was treated with surgical excision. Central giant cell granuloma of the mandible american. Case report open access radiotherapy for recurrent central giant cell granuloma. First expression of primary hyperparathyroidism deepanshugulati, 1 vishalbansal, 1 prajeshdubey, 1 sanjaypandey, 2 andabhinavagrawal 3 department of oral and maxillofacial surgery, subharti dental college, meerut. Rebello,1,mggtorres1,vburgos1,coliveira1,jndossantos2,raazevedo1 andpsfcampos1 1department of oral and maxillofacial radiology, federal university of bahia, school of dentistry, salvador, ba, brazil. We present a child with symptoms of rickets as the first clinical sign of a central giant cell granuloma cgcg with high serum levels of fgf23, a hormone associated with decreased phosphate resorption.
Pdf this article describes a case of central giant cell granuloma in the right posterior region of the mandible in a 10 yearold boy. Intralesional corticosteroid injection for central giant. Intralesional corticosteroid injection for central giant cell. Tumorinduced osteomalaciarickets is a rare paraneoplastic disorder associated with a tumorproducing fibroblast growth factor 23 fgf23. Peripheral giant cell granuloma or so called giant cell epulis is the most common oral giant cell lesion. It is often difficult to make a clinical diagnosis. It is actually an asymptomatic lesion which becomes evident during routine radiographic examination or as a result of painless but visible expansion of. Central giant cell granuloma cgcg, formerly called giant cell reparative granuloma, is a nonneoplastic proliferative lesion of an unknown aetiology. Extra oral examination revealed a diffuse swelling on the left side of face causing slight obliteration of nasio. It usually presents as a purplishred soft tissue nodule consisting of multinucleated giant cells in a background of mononuclear stromal cells and extravasated red blood cells. To the best of our knowledge, the present case is the first report of. Thought to represent a reparative response to intrabony haemorrhage and inflammation, cgcg was once regarded as a reactive lesion.
Central giant cell granuloma cgcg is a rare, nonneoplastic, benign lesion that exhibits expansive. Radiotherapy for recurrent central giant cell granuloma. A case report elisa fernandezcooke, md a, jaime cruzrojo, md, carmen gallego, mdb, ana isabel romance, mdc, rocio mosquedapena, md, yolanda almaden, mdd, jaime sanchez del pozo, mda abstract tumorinduced osteomalaciarickets is a rare paraneoplastic disorder. Giant cell granuloma gcg is an uncommon, benign, proliferative, intraosseous lesion representing granuloma. Central giant cell granuloma was 1st described in jaws by jaffe 1953. Central giant cell granuloma a case report balaji p, balaji. It is an uncommon tumor in jaws, its etiology and pathogenesis is unknown. Pdf central giant cell granuloma cgcg is a benign intraosseous lesion of unknown etiology, and occurs in jaws. Central giant cell granulomas are benign tumours of the mandible, presenting in children and young adults. Giant cell central granuloma gccg is an uncommon pseudotumor of the maxilla. Radiologic features, including those seen with computed tomography, of central giant cell granuloma of the jaws. Peripheral giant cell granuloma is a common benign and reactive gingival epulis in oral cavity. Birgit kruselosler, raihanatou diallo, christoph jaffe2 in 1953. The condition was first identified in 1953 by jaffe, who initially termed this lesion as a central giant cell reparative granuloma, but nowadays the reparative word has been.
It was first described as central giant cell reparative granuloma by jaffe h l in the year 1953. S dental college, hospital and research centre, greater noida, india 2 army dental core, central government of india, india 3 department of oral medicine and radiology, i. Central giant cell granuloma is a benign, aggressive neoplasm composed of multinucleated giant cells that almost exclusively occurs in the. Central giant cell granulomas are benign tumours of the mandible, presenting in children. Achieving the correct diagnosis is reportedly difficult because cgcgs are very similar to odontogenic jaw tumors. Peripheral giant cell granuloma pgcg is a nonneoplastic, tumorlike reactive lesion occurring exclusively on gingivaalveolar crest. Case report central giant cell granuloma of posterior. We report a case of large temporal giant cell reparative granuloma in a 72yearold man. The aim was to evaluate the effectiveness of the longterm administration of intranasal calcitonin spray for the treatment of central giant cell granuloma cgcg in a retrospective case study. A central giant cell granuloma in posterior part of. Central giant cell granuloma cgcg is an uncommon, benign, and proliferative lesion of the jaw with an unknown etiology. Dec 28, 2019 central giant cell granulomas of the condyle are rare. Extremely aggressive behavior of central giant cell. These tumors become severely invasive with the stimulus of surgery, resembling malignant tumors.
Casereport munzenmayer j1, tapia p 2, zeballos j, martinez a 3, compan a4, urra a 5, spencer ml6 summary this case report describes a 19yearold female patient with a central giant cell granuloma in the left mandibular condyle, treated with en bloc resection. Mar 21, 2012 central giant cell granuloma formerly called as giant cell reparative granuloma is a non neoplastic proliferative lesion of unknown etiology. Central giant cell granuloma and fibrous dysplasia. It accounts for 7% benign maxillary tumors, and females are predominantly affected in 23ofcases before age 20years 1. The central giant cell granuloma is often found in the mandible commonly occurring in patients under. We present the case of a 60yearold woman with preauricular swelling, limitation of joint motion and pain on only the right side. A recurrent central giant cell granuloma in a young patient. Pdf agressive central giant cell granuloma of the mandible. Tumorinduced rickets in a child with a central giant cell. Mr imaging depicted a right temporal expansile multiloculated lesion, with hyper and hypointense signal areas on t2weighted images, heterogeneously enhancing after gadolinium administration. The case reported here resembled a wide variety of conditions that led to a misdiagnosis both on clinical and radiographic examinations but was. Jul 18, 2019 central giant cell granulomas are benign tumours of the mandible, presenting in children and young adults. This article describes a case of central giant cell granuloma in the right posterior region of the mandible in a 10 yearold boy. The lesion principally affects the mandible and maxilla and rarely affects the skull or small bones of the hands and feet 2, 3.
Central giant cell granuloma cgcg is a rare, nonneoplastic, benign lesion that exhibits expansive and osteolytic biological behavior. Central giant cell granuloma is a benign intraosseous lesion. Tumorinduced rickets in a child with a central giant cell granuloma. Central giant cell granuloma condyle mandible intraosseous abstract introduction. Jul 19, 2019 central giant cell granuloma cgcg is a rare, nonneoplastic, benign lesion that exhibits expansive and osteolytic biological behavior. Central giant cell granuloma of the maxilla bmj case reports. Central giant cell granuloma a case report balaji p. Central giant cell granuloma is an uncommon, benign, and proliferative lesion whose etiology is not defined. Intralesional corticosteroid injection for central giant cell granuloma. An aggressive central giant cell granuloma in a pediatric. Divided into non and aggressive subtypes, the aggressive subtype is relatively rare and can occasionally progress rapidly, resulting in significant morbidity. Surgical treatment and reconstruction for central giant cell. Fibrous dysplasia is a benign fibroosseous lesion arising in an intramedullary location. Multifocal central giant cell granuloma a case report ncbi.
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